Achievement
Description
Value
A Blank Card (secret)
Kill Isaac with Eden.
15
A Fetus in a Jar
Kill Mom's Heart 9 times.
15
A Quarter
Kill Mom's Heart 8 times.
15
Azazel
Make 3 deals with the devil in one run.
15
Basement Boy
Beat the Basement/Cellar without taking damage.
20
Blood Rights (secret)
Kill Satan with Samson.
15
Bloody Lust (secret)
Kill Isaac with Samson.
15
Blue Baby
Kill Mom's Heart 10 times.
15
Boss Rush (secret)
Beat the Boss Rush.
20
Broken Ankh (secret)
Kill Satan with Lazarus.
15
Cain
Hold 55 or more pennies at one time.
15
Challenges
Beat all 20 Challenges.
20
Daemon's Tail (secret)
Kill Satan with Azazel.
15
Dark Boy
Beat the Depths/Necropolis without taking damage.
20
Dark Room (secret)
Beat the Dark Room.
15
Dead Boy (secret)
Beat the Chest or Dark Room without taking damage.
20
Eden
Beat the Womb for the first time.
15
Eve
Beat 2 levels in a row without picking up any hearts.
15
Eve's Bird Foot (secret)
Kill Isaac with Eve.
15
Everything Is Terrible
Kill Mom's Heart 5 times.
15
Forget Me Now (secret)
Kill Satan with ???.
15
Golden God
You are the best!
30
Guardian Angel (secret)
Kill Satan with Maggy.
15
Isaac's Heart (secret)
Kill Isaac with The Lost.
15
Isaac's Tears (secret)
Kill Isaac with Isaac.
15
It Lives
Kill Mom's Heart 11 times.
15
Judas (secret)
Kill Satan
15
Judas' Tongue (secret)
Kill Satan with Judas.
15
Lazarus
Have 4 or more soul hearts at one time
15
Lazarus' Rags (secret)
Kill Isaac with Lazarus.
15
Little Baggy
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball.
15
Lost Poster (secret)
Beat the Dark Room with Isaac.
15
Magdalene
Have 7 or more max red hearts at one time.
15
Mama's Boy
Beat the Womb/Utero without taking damage.
20
Mom's Knife (secret)
Kill Satan with Isaac.
15
Platinum God
Collect all items and unlock all secrets and endings.
40
Real Platinum God (secret)
100% the game!
50
Samson
Beat 2 levels in a row without taking damage.
15
Something Cute
Beat the Caves 30 times.
15
Something from the Future
Beat the Basement 40 times.
15
Something Sticky
Beat the Depths 20 times.
15
Spelunker Boy
Beat the Caves/Catacombs without taking damage.
20
The Bomb Bag (secret)
Kill Satan with Cain.
15
The Book of Secrets (secret)
Kill Satan with Eden.
15
The Book of Sin
Kill all 7 sins.
15
The Chest (secret)
Beat the Chest.
15
The Coin Bag (secret)
Kill Isaac with Cain.
15
The Guillotine (secret)
Kill Isaac with Judas.
15
The Halo
Kill Mom using the Bible.
15
The Lost (secret)
Finish the game's final secret.
20
The Mind (secret)
Kill Satan with The Lost.
15
The Negative (secret)
Beat Sheol 5 times.
20
The Polaroid (secret)
Beat Cathedral 5 times.
20
The Razor (secret)
Kill Satan with Eve.
15
The Relic (secret)
Kill Isaac with Maggy.
15
The Satanic Bible (secret)
Kill Isaac with Azazel.
15
Transcendence
Kill Mom's Heart 3 times.
15