Complete the game once on any difficulty to gain the Special Key to open the costume room where you can change you clothes after completing the game the required amount of times.
Jill's Sarah Connor costume: Complete the game once with Jill on any difficulty.
Jill's Resident Evil 3 costume: Clear the game twice with Jill on any difficulty.
Chris' The Mexican costume: Clear the game once with Chris on any difficulty to unlock his costume where he dresses up like Brad Pitt from the movie The Mexican. Rebecca also changes her costume to look like Julia Roberts from The Mexican.
Chris' CODE Veronica costume: Clear the game twice with Chris on any difficulty.
Successfully complete the game as Jill or Chris in once again mode under the normal difficulty setting with a time less than five hours. Save the game at the end, then start a new game to begin with the Samurai Edge gun.
James Forrest.
Successfully complete the game as Jill or Chris with a time less than three hours. Save the game at the end, then start a new game to begin with the Rocket Launcher with unlimited ammunition.
Successfully complete the game in once again mode under the normal difficulty setting with a time less than five hours and thirty minutes. This unlocks the "Real Survivor" option (item boxes do not transfer items to each other) and bonus costumes. Additionally, the aiming system will be manual.
Michael Lane.
Successfully complete the game two times as Jill or Chris to unlock the "Invisible Enemy" option. All enemies will be transparent in this mode.
Successfully complete the game as both Jill and Chris one time to unlock the "One Dangerous Zombie" option. When this option is enabled, a special zombie will keep following you around during the first part of the game. Shooting this zombie will end the game, so you must avoid it during game play.
Successfully complete the game in invisible enemy mode with a time less than five hours to unlock a "Special Features" option that displays a message from the game developers and a gallery of pre-production costumes.