When on the bridge between the park and the lab, choose to jump off the bridge instead of pushing Nemesis off, it changes the end of the game along with other scenes through the rest of the game.
To read the director's message. beat the game 8 times. Note: this is the only chance you get to read it.
When you beat the game for the first 8 times, you would be awarded 8 different Epilogue Files of 8 different Resident Evil Characters, telling you what has happened to each of them after their adventures. Here's the order that you can unlock them in: