Get all the items from every trashcan, chest, or box you find, especially the SaberSense Chips. The more SaberSense Chips you have, the more you can build them up to buy health, ammo, weapons, and upgrades from the Kiosks. Also, collecting ammo is helpful. Mooch can be useful; let him scour the areas for SaberSense Chips.
After hitting a trash can or chest to get items out of it, if the lid closes you may hit the same trashcan or chest repeatedly until the lid remains completely open. Each time you hit the same trashcan, more items will appear for you to collect, such as ammo, health, etc.
Always use the Electro Whip as much as possible on enemies. Save your weapons for enemies that are at further distances. Some flying enemies are difficult to hit with the electro whip. You can hit flying enemies with the electro whip if you are skilled in using it. If you must use weapons, use them sparingly.
Successfully complete the game.