Go upstairs at Ghostbusters headquarters. You can find a drawing by a child on pink paper hanging near some electrical equipment. The text "To Uncle Egon, from Ed." Appears on it. This is a reference to the fan fiction Ghostbusters videos "Freddy vs. Ghostbusters" and "The Return Of The Ghostbusters" which features Egon's nephew Ed Spengler.
In the museum, when you are chasing the Chairman with Alyssa, you will enter an exhibit that shows the burial customs of the Gozerian Cult. Once you enter this room, immediately turn to the right and you will see three portraits in the dark. Use the Stasis Stream to illuminate the painting. You will see a skeleton creature kissing a woman, but he has pulled up her dress and appears to be touching her.
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In the HQ, walk to the windows on the back left and you will see the doors from the Ecto 2 along with the logo from Ghostbusters 2