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Successfully complete Story mode with any character to unlock an alternate costume for that person.
When you complete Story mode with a character that has a costume and you destroy the credits, Mandy will be in a costume.
To unlock a second set of costumes, successfully complete all fifteen Mission mode matches.

Hold 1 and press Up two times, Down two times, Left, Right, Left, Right at the main menu.

Successfully complete Story mode with all characters and accumulate 10 hours of game play time to unlock Chicken.

Get 200,000 damage points and play over 100 verses battles.

Successfully complete Story mode with Billy, Mandy, Grim, or Irwin to unlock Eris.