Destroy All Humans!
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1337 DNA
Pause the game while on the Mothership, then hold L and press Black(2), White(2), L, R, L, R, White, Black.
B-Movie Theater bonuses
Complete the indicated level to unlock the corresponding movie under the B-Movie Theater option.
Better DNA value
Every chance you get, do not kill a human before you extract their brain stem. Extract their brain stem first as it will make the DNA worth more (25 instead of 10). The easiest humans to do this to are the scientists in the level with glowing cows. For some reason, if the person that is important to you dies (the person you need to abduct), extract their brain stem before you return to the Mothership -- the DNA is usually worth more. Additionally, it is rare to find humans with brain stems that are worth 50 or 100 DNA. Most humans have brain stems that are only worth 10 or 25 DNA. If you walk around Union Town, there will be humans with signs on them reading, "REPENT THE END IS NEAR". Those humans will have a brain stem worth 50 DNA. Also, Mystery Agents' brain stems are worth 25 DNA points most of the time, whether dead or not.
Control objects
When you pick something up, you can control it with the Right Analog-stick.
Deep Thinker (infinite concentration)
Pause the game, then hold L and press Black, White, Y, Right, White, Y. Your concentration meter must be above 0% or you will not be able to use any of your mental abilities.