To stock up on healing powder, have the shaman make it for you in the village of Arrayo. Note: It is easier to find the Broc Flowers at night because they stay orange even at that time. The Xander Root is not as plentiful, but is still fairly easy to find. It is a tiny stalk of weeds, usually found in a cleared path. Be careful when using Healing Powder during battle because you will lose your aim. Hitting your target will become more difficult.
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There is a mutant called Marcus that wearing black leather armor and has a big minigun. In order to have him join you, you must frame the two humans who want to get rid of the mutants. You also will have to fix their mine with an air-cleaning device.
You can find chips to get skill upgrades in the various cities. After finding some, go to San Francisco. There is a man standing near a building that you cannot enter. Talk to him. He is from the Brotherhood Of The Steel. Complete his mission by going to Navarro and getting the Vertibird plans. He will now let you inside the building. Once underground you can find nice armor and weapons. You can also find the A.C.E. computer. You can use them at A.C.E. to increase various skills.
When you are traveling from Vault 15 to Broken Hills, if you have the Fortune Finder perk you might find a Federation Shuttle.
Play the game with an Intelligence of 3 or less, or use some doses of Psyco. Some characters will refuse to speak with you. Other characters will speak to you, but with funny dialogue. Note: Try the slot machines.
Lenny is a Ghoul living in Gecko city. He is in the first or second house on the right when you enter Gecko City. Just talk to him and he will join you.
After completing the game, go to New Reno. Find theman in the church and talk to him. He will say thanks for killingthe Enclave and will give you a book called the "Fallout2 Hint Book". Every time you read it, you will gain 10000experience points. After the first time you read it, all of yourskill will go up to 300%. You can read this book as many timesas needed and it will never go away.